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. 1998 Dec 31;37(24):3387-3388.
doi: 10.1002/(SICI)1521-3773(19981231)37:24<3387::AID-ANIE3387>3.0.CO;2-P.

A Convenient and General Method for Pd-Catalyzed Suzuki Cross-Couplings of Aryl Chlorides and Arylboronic Acids

Adam F Littke  1 , Gregory C Fu  1
Affiliations

A Convenient and General Method for Pd-Catalyzed Suzuki Cross-Couplings of Aryl Chlorides and Arylboronic Acids

Adam F Littke et al. Angew Chem Int Ed Engl. .

Abstract

From only commercially available reagents a wide array of Suzuki cross-couplings of aryl chlorides with arylboronic acids can be effected in excellent yield [Eq. (a)]. This development provides a general solution to a long-standing limitation of this extremely powerful process-the poor reactivity of inexpensive and readily accessible aryl chlorides. dba=dibenzylideneacetone.

Keywords: Cross-coupling; Homogeneous catalysis; Palladium; Suzuki reaction.

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