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. 1988 Oct 6;335(6190):519-25.
doi: 10.1038/335519a0.

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

N Sagata  1 , M Oskarsson, T Copeland, J Brumbaugh, G F Vande Woude
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Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

N Sagata et al. Nature. .

Abstract

The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.

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