Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Dec 17;37(23):3281-3284.
doi: 10.1002/(SICI)1521-3773(19981217)37:23<3281::AID-ANIE3281>3.0.CO;2-V.

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

Helen E Blackwell  1 , Robert H Grubbs  1
Affiliations

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

Helen E Blackwell et al. Angew Chem Int Ed Engl. .

Abstract

Olefin metathesis has been successfully applied to the synthesis of macrocyclic helical peptides [Eq. (a)]. Carbon-carbon bond tethers between amino acid side chains were introduced by ring-closing metathesis. This macrocyclization protocol is a novel and mild procedure for introducing nonnative covalent cross-links into peptide helices.

Keywords: Carbene complexes; Helical structures; Macrocycles; Metathesis; Peptides.

PubMed Disclaimer

LinkOut - more resources