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. 1998 Apr 20;37(7):992-994.
doi: 10.1002/(SICI)1521-3773(19980420)37:7<992::AID-ANIE992>3.0.CO;2-P.

Direct Observation of Radical Intermediates While Investigating the Redox Behavior of Thiamin Coenzyme Models

Ikuo Nakanishi  1 , Shinobu Itoh  1 , Tomoyoshi Suenobu  1 , Shunichi Fukuzumi  1
Affiliations

Direct Observation of Radical Intermediates While Investigating the Redox Behavior of Thiamin Coenzyme Models

Ikuo Nakanishi et al. Angew Chem Int Ed Engl. .

Abstract

The redox behavior of "active aldehydes" 1- derived from 3-benzylthiazolium salts and simple aldehydes in the presence of a base has been examined with low-temperature cyclic voltammetry and EPR spectroscopy. The highly negative oxidation potentials of 1- and the spin distribution of the intermediate radicals 1. indicate that the active aldehyde can act as an efficient electron mediator in thiamin-dependent enzymatic redox systems.

Keywords: Coenzymes; Cyclic voltammetry; EPR spectroscopy; Radicals; Thiamin.

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