Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Mar 1;38(5):643-647.
doi: 10.1002/(SICI)1521-3773(19990301)38:5<643::AID-ANIE643>3.0.CO;2-G.

Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds

Thomas Henkel  1 , Roger M Brunne  2 , Hartwig Müller  1 , Felix Reichel  3
Affiliations

Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds

Thomas Henkel et al. Angew Chem Int Ed Engl. .

Abstract

The potential of new natural products as an important source for the exploration and development of new drugs and crop protection products is a long way from being exhausted. The statistical analysis of the structures of the natural and synthetically derived compounds has shown conspicuous variations in structural types in the natural products derived from different natural sources, which can be utilized in the search for individual active substances. The occasionally voiced prepossession that natural products have already been sufficiently examined and therefore no more innovations are to be expected can definitely be rejected.

Keywords: Drug research; Molecular diversity; Natural products; Statistical analysis; Structural properties.

PubMed Disclaimer

LinkOut - more resources