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. 1999 May 17;38(10):1466-1468.
doi: 10.1002/(SICI)1521-3773(19990517)38:10<1466::AID-ANIE1466>3.0.CO;2-#.

Carbohydrate-Carbohydrate Recognition between LewisX Glycoconjugates

Armin Geyer  1 , Christian Gege  1 , Richard R Schmidt  1
Affiliations

Carbohydrate-Carbohydrate Recognition between LewisX Glycoconjugates

Armin Geyer et al. Angew Chem Int Ed Engl. .

Abstract

The strong dependence of the NOE on the molecular mobility rendered the weak bond of a homotypical carbohydrate-carbohydrate recognition detectable in a simplified model system. The membrane-bound LeX trisaccharide 1, which functions as a receptor, transiently binds the dissolved LeX trisaccharide 2, thus slowing down its rotational diffusion. This kind of molecular recognition plays an important part in cell adhesion.

Keywords: Carbohydrates; LewisX antigens; Membranes; Molecular recognition; NMR spectroscopy.

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