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. 1998 Oct 16;37(19):2673-2675.
doi: 10.1002/(SICI)1521-3773(19981016)37:19<2673::AID-ANIE2673>3.0.CO;2-#.

Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes

Silvio Aime  1 , Alessandro Barge  1 , Mauro Botta  1 , Alvaro S De Sousa  2 , David Parker  2
Affiliations

Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes

Silvio Aime et al. Angew Chem Int Ed Engl. .

Abstract

A large difference in the exchange rate of the coordinated water molecule is seen in solution for the diastereoisomers M and m of a europium(III) complex with an octadentate, neutral macrocyclic ligand (kex (M)<kex (m)). This finding is of high relevance to the design of more efficient contrast agents for magnetic resonance imaging.

Keywords: Lanthanides; Macrocyclic ligands; NMR spectroscopy; Water exchange.

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