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Review
. 1998 Oct 16;37(19):2562-2579.
doi: 10.1002/(SICI)1521-3773(19981016)37:19<2562::AID-ANIE2562>3.0.CO;2-D.

Use of Lewis Acids in Free Radical Reactions

Philippe Renaud  1 , Michèle Gerster  1
Affiliations
Review

Use of Lewis Acids in Free Radical Reactions

Philippe Renaud et al. Angew Chem Int Ed Engl. .

Abstract

The neglect of free radicals over the past few years has been overcome, and they are no longer only considered as interesting reactive intermediates with limited synthetic potential. New opportunities are opened up by performing radical reactions in the presence of Lewis acids. Rate enhancement of radical addition to olefins as well as stereochemical control of such reactions can be achieved in a unique manner. Recent examples of enantioselective radical reactions and perspectives for applications in catalysis are discussed.

Keywords: Asymmetric synthesis; Chelates; Lewis acids; Radical reactions; Radicals.

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