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. 1999 Feb 1;38(3):326-329.
doi: 10.1002/(SICI)1521-3773(19990201)38:3<326::AID-ANIE326>3.0.CO;2-T.

Sharpless Asymmetric Aminohydroxylation: Scope, Limitations, and Use in Synthesis

Peter O'Brien  1
Affiliations

Sharpless Asymmetric Aminohydroxylation: Scope, Limitations, and Use in Synthesis

Peter O'Brien. Angew Chem Int Ed Engl. .

Abstract

As a valuable methodology for organic synthesis, asymmetric aminohydroxylation (AA)-the catalytic and asymmetric conversion of alkenes into enantiomerically enriched N-protected amino alcohols-has become established in a remarkably short period of time. Examples of the types of products that can be synthesized easily on a reasonably large scale and in enantiomerically pure form are shown in the picture.

Keywords: Amino alcohols; Aminohydroxylations; Asymmetric catalysis; Asymmetric synthesis; Osmium.

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