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. 1999 May 3;38(9):1263-1266.
doi: 10.1002/(SICI)1521-3773(19990503)38:9<1263::AID-ANIE1263>3.0.CO;2-2.

Total Synthesis of (-)-Mucocin

Stefan Bäurle  1 , Sabine Hoppen  1 , Ulrich Koert  1
Affiliations

Total Synthesis of (-)-Mucocin

Stefan Bäurle et al. Angew Chem Int Ed Engl. .

Abstract

A highly convergent, modular strategy for the total synthesis of the annonaceous acetogenin (-)-mucocin is reported. The remarkable features are the endo-selective formation of the tetrahydropyran ring from an activated epoxide and the stability of the butenolide in the coupling with an organomagnesium compound.

Keywords: Annonins; Antitumor agents; Mucocin; Natural products; Total synthesis.

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