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. 2001 Sep 3;40(17):3204-3206.
doi: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H.

Magnetic Nanosensors for the Detection of Oligonucleotide Sequences

Lee Josephson  1 , J Manuel Perez  1 , Ralph Weissleder  1
Affiliations

Magnetic Nanosensors for the Detection of Oligonucleotide Sequences

Lee Josephson et al. Angew Chem Int Ed Engl. .

Abstract

Superparamagnetic nanoparticles conjugated to oligonucleotides exert sensitive and reversible effects on the spin-spin relaxation rates of adjacent water protons when the conjugates hybridize to target oligonucleotides (see temperature cycle in the picture). The fluid-phase magnetic sensors provide the basis for detecting specific nucleic acid sequences in turbid media and potentially in tissues in vivo.

Keywords: DNA recognition; magnetic properties; nanostructures; oligonucleotides.

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