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. 2001 Nov 19;40(22):4239-4242.
doi: 10.1002/1521-3773(20011119)40:22<4239::AID-ANIE4239>3.0.CO;2-E.

Artificial Enzymes Formed through Directed Assembly of Molecular Square Encapsulated Epoxidation Catalysts

Melissa L Merlau  1 , Maria Del Pilar Mejia  1 , SonBinh T Nguyen  1 , Joseph T Hupp  1
Affiliations

Artificial Enzymes Formed through Directed Assembly of Molecular Square Encapsulated Epoxidation Catalysts

Melissa L Merlau et al. Angew Chem Int Ed Engl. .

Abstract

Supramolecular complex formation imparts stability and substrate selectivity to a simple manganese-porphyrin-based epoxidation catalyst. Lewis acid/Lewis base directed assembly was used to encapsulate the epoxidation catalyst within a supramolecular square structure to form an enzyme-like catalyst system. The "molecular square" takes on the functions of the protein superstructure in an enzyme: it spatially protects the catalytic core from decomposition and induces reaction selectivity.

Keywords: epoxidation; homogeneous catalysis; host-guest systems; self-assembly; supramolecular chemistry.

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