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. 2001 Nov 19;40(22):4289-4291.
doi: 10.1002/1521-3773(20011119)40:22<4289::AID-ANIE4289>3.0.CO;2-4.

Testing Racemic Chiral Catalysts for Kinetic Resolution Potential

Beatriz Dominguez  1 , Neil S Hodnett  1 , Guy C Lloyd-Jones  1
Affiliations

Testing Racemic Chiral Catalysts for Kinetic Resolution Potential

Beatriz Dominguez et al. Angew Chem Int Ed Engl. .

Abstract

An even-handed approach: by use of an enantiomerically enriched substrate and study of the changes in enantiomer ratio of substrate under pseudo zero-order conditions, racemic catalysts may be employed to determine whether the enantiomerically pure catalyst would be effective for kinetic resolution of the racemic substrate (see scheme; E=CO2 Me).

Keywords: allylation; asymmetric catalysis; kinetic resolution; palladium.

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