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Review
. 2018 Jun;71(6):1015-1022.
doi: 10.1161/HYPERTENSIONAHA.118.10267. Epub 2018 Apr 30.

Beneficial Effects of High Potassium: Contribution of Renal Basolateral K+ Channels

Alexander Staruschenko  1
Affiliations
Review

Beneficial Effects of High Potassium: Contribution of Renal Basolateral K+ Channels

Alexander Staruschenko. Hypertension. 2018 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Mortality rate of SHR (A) and Dahl SS (B) rats challenged with the high salt diet supplemented with either normal or high dietary K+ intake. The actual final concentration of K+ in each diet is listed. For these experiments SHR rats were fed a 4% NaCl diet for 17 weeks, and Dahl SS rats were fed an 8% NaCl diet for 9 weeks. Redrawn and adapted from Tobian et al with permission from the publisher.
Figure 2
Figure 2
Model of electrolyte transport in the early and late distal convoluted tubule (DCT1 and DCT2, respectively) (A) and the principal cells of cortical collecting duct (CCD) (B).
Figure 3
Figure 3
Expression and electrophysiological analysis of Kir4.1 homotetrameric and Kir4.1/Kir5.1 heterotetrameric channels. (A) Double immunostaining images show Kir5.1 expression (red) in the distal convoluted (DCT) and cortical collecting duct (CCD) cells. Aqp2 (green) was used as a marker of CD principal cells. Proximal tubules (PT) and glomerulus (G) are also shown. Scale bar is 20 μm. (B) Representative current traces and (C) current-voltage (I/V) relationships of the unitary current amplitude of Kir4.1 and Kir4.1/Kir5.1 channels measured in Dahl SS rats. Shown at −80 mV is activity of both heteromeric Kir4.1/Kir5.1 and homomeric Kir4.1 channels in the same patch. Adapted from Palygin al with permission from the publisher.
Figure 4
Figure 4
High salt intake triggers rapid mortality of SSKcnj16−/− rats which is rescued by supplementation of high potassium. (A) Survival rate of SS and SSKcnj16−/− rats on a low potassium (0.36% K+) and 4% NaCl diet. (B) Mean arterial pressure in SS and SSKcnj16−/− rats. Animals were switched from a 0.4% to a 4% NaCl diet at day 0. Then, SS rats were fed either a standard 4% NaCl diet (black) or a 4% NaCl diet supplemented with high K+ (1.41% K+; green). SSKcnj16−/− rats were fed a 4% diet supplemented with high K+ (red). Adapted from Palygin et al with permission from the publisher.
See this image and copyright information in PMC

References

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