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Review
. 2018 Apr 17:11:2185-2193.
doi: 10.2147/OTT.S157058. eCollection 2018.

The role of Hippo signal pathway in breast cancer metastasis

Changran Wei  1 , Ying Wang  2 , Xiangqi Li  1
Affiliations
Review

The role of Hippo signal pathway in breast cancer metastasis

Changran Wei et al. Onco Targets Ther. .

Abstract

The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis.

Keywords: Hippo signal pathway; breast cancer; metastasis.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Regulation of the core components of the Hippo signaling pathway. Abbreviation: ER, estrogen receptor.
Figure 2
Figure 2
The Hippo pathway regulates organ metastases by controlling cell proliferation, EMT, and immune evasion. Abbreviation: EMT, epithelial–mesenchymal transition.
See this image and copyright information in PMC

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