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Review
. 2018 Apr 23:7:9.
doi: 10.1186/s40035-018-0114-z. eCollection 2018.

Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer's dementia: a meta-analysis

Hai Rong Ma  1 , Li Qin Sheng  1 , Ping Lei Pan  2 , Gen Di Wang  2 , Rong Luo  2 , Hai Cun Shi  2 , Zhen Yu Dai  3 , Jian Guo Zhong  2
Affiliations
Review

Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer's dementia: a meta-analysis

Hai Rong Ma et al. Transl Neurodegener. .

Abstract

Brain 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to monitor disease conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer's dementia (AD). However, the conversion patterns of FDG-PET metabolism across studies are not conclusive. We conducted a voxel-wise meta-analysis using Seed-based d Mapping that included 10 baseline voxel-wise FDG-PET comparisons between 93 aMCI converters and 129 aMCI non-converters from nine longitudinal studies. The most robust and reliable metabolic alterations that predicted conversion from aMCI to AD were localized in the left posterior cingulate cortex (PCC)/precuneus. Furthermore, meta-regression analyses indicated that baseline mean age and severity of cognitive impairment, and follow-up duration were significant moderators for metabolic alterations in aMCI converters. Our study revealed hypometabolism in the left PCC/precuneus as an early feature in the development of AD. This finding has important implications in understanding the neural substrates for AD conversion and could serve as a potential imaging biomarker for early detection of AD as well as for tracking disease progression at the predementia stage.

Keywords: Alzheimer’s dementia; Conversion; FDG-PET; Meta-analysis; Mild cognitive impairment; Seed-based d mapping.

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Conflict of interest statement

This article does not contain any studies with human participants performed by any of the authors.The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart for the literature search. Abbreviations: MCI, mild cognitive impairment; AD, Alzheimer’s dementia; FDG-PET, 18F-fluorodesoxyglucose positron emission tomography; aMCI, amnestic MCI
Fig. 2
Fig. 2
Brain hypometabolism map for the main voxel-wise meta-analysis in aMCI converters and aMCI non-converters. Abbreviations: aMCI, amnestic mild cognitive impairment; L, left; R, right; SDM, Seed-based d Mapping. The color bar indicates the maximum and the minimum SDM-Z values
See this image and copyright information in PMC

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