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. 2018 Apr:20:67-74.
doi: 10.1016/j.cobeha.2017.11.005. Epub 2017 Nov 21.

Regulation of habit formation in the dorsal striatum

Melissa Malvaez  1 , Kate M Wassum  1   2
Affiliations

Regulation of habit formation in the dorsal striatum

Melissa Malvaez et al. Curr Opin Behav Sci. 2018 Apr.

Abstract

Habits are an essential and pervasive component of our daily lives that allow us to efficiently perform routine tasks. But their disruption contributes to the symptoms that underlie many psychiatric diseases. Emerging data are revealing the cellular and molecular mechanisms of habit formation in the dorsal striatum. New data suggest that in both the dorsolateral and dorsomedial striatum histone deacetylase (HDAC) activity acts as a critical negative regulator of the transcriptional processes underlying habit formation. In this review, we discuss this recent work and draw conclusions relevant to the treatment of diseases marked by maladaptive habits.

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Conflict of interest statement

Conflicts of interest The authors have no actual or potential conflicts of interests to declare.

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