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. 1988 Jun:9 Suppl H:21-7.
doi: 10.1093/eurheartj/9.suppl_h.21.

Atrial natriuretic factor in experimental and human hypertension

M Cantin  1 , R Garcia, G Thibault, O Kuchel, J Gutkowska, P Larochelle, P Hamet, E L Schiffrin, J Genest
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Atrial natriuretic factor in experimental and human hypertension

M Cantin et al. Eur Heart J. 1988 Jun.

Abstract

Plasma levels of immunoreactive atrial natriuretic factor (IR-ANF) were evaluated by radioimmunoassay in several models of experimental hypertension and in human hypertension. Plasma levels of IR-ANF are consistently increased in all models of experimental hypertension studied so far. This is accompanied by a decrease of IR-ANF levels in the left atrium at certain times. Plasma levels of IR-ANF are not increased in human essential hypertension, except in the severe form (diastolic blood pressure above 110 mmHg). Peripheral levels of IR-ANF in renovascular hypertension do not differ from normal but are increased above normal in aortic blood.

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