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. 2018 Mar-Apr;70(2):225-232.
doi: 10.1016/j.ihj.2017.06.019. Epub 2017 Jul 1.

Assessment of periodontitis and its role in viridans streptococcal bacteremia and infective endocarditis

Shree Dhotre  1 , Vilas Jahagirdar  2 , Namdev Suryawanshi  3 , Milind Davane  3 , Ramesh Patil  4 , Basavraj Nagoba  5
Affiliations

Assessment of periodontitis and its role in viridans streptococcal bacteremia and infective endocarditis

Shree Dhotre et al. Indian Heart J. 2018 Mar-Apr.

Abstract

Objectives: To evaluate the role of periodontitis in viridans group streptococci (VGS) bacteremia and infective endocarditis (IE).

Methods: A total of 200 subjects including two groups. Group A- 34 subjects undergoing tooth extraction with periodontitis, 46 subjects undergoing tooth extraction without periodontitis and 40 healthy controls. Group B: 40 confirmed cases of IE (17 with and 23 without periodontitis) and 40 healthy controls. Subgingival plaque and blood samples were obtained and processed by standard procedures.

Results: A total of 53 blood samples (66.25%) yielded positive cultures after tooth extraction. The relationship between the presence of periodontitis and a positive blood culture was significantly higher (p=0.05) for tooth extraction cases with periodontitis (79.40%) than tooth extraction cases without periodontitis (56.50%). Periodontitis was observed in 42.5% of IE cases. Out of the 40 patients of IE, the blood samples yielded 40 different isolates, majority were viridans streptococci 15 (37.5%) and staphylococci nine (22.5%). No statistically significant difference was observed between the subgingival plaque and blood isolates of periodontitis in both the groups, indicating similarity of biotypes of viridans streptococci isolated from the blood and the subgingival plaque. Similarity was also observed between the antibiogram profiles of viridans streptococci from both the groups.

Conclusions: Periodontitis enhances viridans streptococcal bacteremia and may be a potential risk factor for IE.

Keywords: Infective endocarditis; Periodontitis; Viridans group streptococci.

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Figures

Chart 1
Chart 1
Incidence of post extraction bacteremia related to clinical attachment loss (CAL), periodontal pocket depth (PD), gingival index (GI), papillary bleeding index (PBI) and plaque index (PI). All values are presented in (Mean ± standard deviation).
See this image and copyright information in PMC

References

    1. Bartova J., Sommerova P., Lyuya-Mi Y. Periodontitis as a risk factor of atherosclerosis. J Immunol Res. 2014;2014 636893. Epub 2014 Mar 23. Review. PMID:24741613. - PMC - PubMed
    1. Noack B., Genco R.J., Trevisan M., Grossi S., Zambon J.J., De Nardin E. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol. 2001;72:1221–1227. - PubMed
    1. Ito H.O. Infective endocarditis and dental procedures: evidence, pathogenesis, and prevention. J Med Invest. 2006;53:189–198. - PubMed
    1. Lockhart P.B., Brennan M.T., Thornhill M. Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia. J Am Dent Assoc. 2009;140:1238–1244. - PMC - PubMed
    1. Forner L., Larsen T., Kilian M., Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol. 2006;33:401–407. - PubMed