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Review
. 2018 Jul;7(13):e1701400.
doi: 10.1002/adhm.201701400. Epub 2018 May 2.

Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens

Rajamani Lakshminarayanan  1 , Enyi Ye  2 , David James Young  2   3 , Zibiao Li  2 , Xian Jun Loh  1   2   4
Affiliations
Review

Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens

Rajamani Lakshminarayanan et al. Adv Healthc Mater. 2018 Jul.

Abstract

The rapid growth of harmful pathogens and their multidrug-resistance poses a severe challenge for health professionals and for the development of new healthcare products. Various strategies are exploited for the development of effective antimicrobial agents, and nanoparticles are a particularly promising class of materials in this respect. This review summarizes recent advances in antimicrobial metallic, polymeric, and lipid-based nanoparticles such as liposomes, solid lipid nanoparticles, and nanostructured lipid carriers. The latter materials in particular are engineered for antimicrobial agent delivery and act by encapsulation, receptor-based binding, and disruption of microbial adherence to cellular substrates. Potential strategies for the design of multifunctional antimicrobial nanocarriers, combining material chemistry and biological interface science, are also discussed.

Keywords: antimicrobial; formulations; nanoparticles; pathogens; resistant.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Number of publications on antimicrobial nanoparticles over the period 2002–2017. Data extracted from PubMed.
Figure 2
Figure 2
Proposed antimicrobial mechanisms of metallic nanoparticles by disrupting cell membrane metabolism. Reproduced with permission.27 Copyright 2014, Elsevier.
Figure 3
Figure 3
Schematic illustration showing cationic and hydrophobic functionalized Au NPs used for combating of MDR bacteria. Reproduced with permission.38 Copyright 2014, American Chemical Society.
Figure 4
Figure 4
Schematic representation illustrating antimicrobial activity of copper nanoparticles against bacteria, fungi, and viruses. Reproduced with permission.39 Copyright 2014, Springer.
Figure 5
Figure 5
Schematic illustration showing the self‐assembly of PEO‐PCL‐PTBAM block copolymer into micelles in aqueous solution, postulated to interact with bacterial membranes through electrostatic interactions. Reproduced with permission.70 Copyright 2012, Royal Society of Chemistry.
Figure 6
Figure 6
Liposomes are efficient carriers for drug delivery. Reproduced with permission.81 Copyright 2012, Hindawi.
Figure 7
Figure 7
The design strategy for lipid polymer nanoparticles to eradicate bacterial biofilms. Reproduced with permission.103 Copyright 2015, Elsevier.
See this image and copyright information in PMC

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