Asparagine and Glutamine: Co-conspirators Fueling Metastasis

Ming Luo¹, Michael Brooks², Max S Wicha³

Affiliations

¹ University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mingluo@med.umich.edu.
² University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
³ University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mwicha@med.umich.edu.

PMID: 29719230
DOI: 10.1016/j.cmet.2018.04.012

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Asparagine and Glutamine: Co-conspirators Fueling Metastasis

Ming Luo et al. Cell Metab. 2018.

Free article

. 2018 May 1;27(5):947-949.

doi: 10.1016/j.cmet.2018.04.012.

Authors

Ming Luo¹, Michael Brooks², Max S Wicha³

Affiliations

¹ University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mingluo@med.umich.edu.
² University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
³ University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mwicha@med.umich.edu.

PMID: 29719230
DOI: 10.1016/j.cmet.2018.04.012

Abstract

Cancer cells frequently hijack normal metabolic pathways to promote their growth and metastasis. Two recent papers by Knott et al. (2018) and Pavlova et al. (2018) demonstrate that asparagine and glutamine work in concert to drive tumor growth and metastasis through modulation of cell survival, growth, and EMT regulatory pathways.

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As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.
Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J. Pavlova NN, et al. Cell Metab. 2018 Feb 6;27(2):428-438.e5. doi: 10.1016/j.cmet.2017.12.006. Epub 2018 Jan 11. Cell Metab. 2018. PMID: 29337136 Free PMC article.
Asparagine bioavailability governs metastasis in a model of breast cancer.
Knott SRV, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, Turgeon MO, Fish L, Erard N, Gable AL, Maceli AR, Dickopf S, Papachristou EK, D'Santos CS, Carey LA, Wilkinson JE, Harrell JC, Perou CM, Goodarzi H, Poulogiannis G, Hannon GJ. Knott SRV, et al. Nature. 2018 Feb 15;554(7692):378-381. doi: 10.1038/nature25465. Epub 2018 Feb 7. Nature. 2018. PMID: 29414946 Free PMC article.

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Asparagine and Glutamine: Co-conspirators Fueling Metastasis

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Asparagine and Glutamine: Co-conspirators Fueling Metastasis

Authors

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Abstract

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Grants and funding

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Full Text Sources

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Medical