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. 2018 May 2;8(1):6908.
doi: 10.1038/s41598-018-24757-6.

Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population

Tian-Jong Chang  1   2 , Cai-Mei Zheng  3   4   5 , Mei-Yi Wu  3   4 , Tzu-Ting Chen  6 , Yun-Chun Wu  6 , Yi-Lien Wu  7   8 , Hsin-Ting Lin  9 , Jing-Quan Zheng  1   10 , Nain-Feng Chu  11   12 , Yu-Me Lin  13 , Sui-Lung Su  11 , Kuo-Cheng Lu  14 , Jin-Shuen Chen  15 , Fung-Chang Sung  16 , Chien-Te Lee  17 , Yu Yang  18 , Shang-Jyh Hwang  19 , Ming-Cheng Wang  20 , Yung-Ho Hsu  3   4 , Hung-Yi Chiou  13 , Senyeong Kao  21   22 , Yuh-Feng Lin  23   24   25   26   27   28
Affiliations

Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population

Tian-Jong Chang et al. Sci Rep. .

Erratum in

Abstract

This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flowchart of Patients Selection.
Figure 2
Figure 2
Association between body mass index and the risk of estimated glomerular filtration rate progression among patients with chronic kidney disease stages 1–5.
Figure 3
Figure 3
Association between body mass index and the risk of estimated glomerular filtration rate progression among patients with chronic kidney disease stages 1–3a.
Figure 4
Figure 4
Association between body mass index and the risk of estimated glomerular filtration rate progression among patients with chronic kidney disease stages 3b–5.
Figure 5
Figure 5
Charlson comorbidity score according to body mass index in patients with chronic kidney disease stages 1–5.
See this image and copyright information in PMC

References

    1. Yeh CJ, Chang HY, Pan WH. Time trend of obesity, the metabolic syndrome and related dietary pattern in Taiwan: from NAHSIT 1993–1996 to NAHSIT 2005–2008. Asia Pac J Clin Nutr. 2011;20:292–300. - PubMed
    1. HPA. Taiwanese Survey on Hypertension, Hyperglycemia, and Hyperlipidemia. (Health Promotion Administration, Ministry of Health and Welfare, 2007).
    1. Foster MC, et al. Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study. Am J Kidney Dis. 2008;52:39–48. doi: 10.1053/j.ajkd.2008.03.003. - DOI - PMC - PubMed
    1. Ejerblad E, et al. Obesity and risk for chronic renal failure. J Am Soc Nephrol. 2006;17:1695–1702. doi: 10.1681/ASN.2005060638. - DOI - PubMed
    1. Fox CS, et al. Predictors of new-onset kidney disease in a community-based population. JAMA. 2004;291:844–850. doi: 10.1001/jama.291.7.844. - DOI - PubMed

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