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. 2018 Apr 3;10(1):7070.
doi: 10.4081/hr.2018.7070. eCollection 2018 Mar 2.

Extranodal diffuse large B-cell lymphomas: A retrospective case series and review of the literature

Stergios Boussios  1   2 , Ioannis Zerdes  1   2 , Amalia Vassou  2   3 , Eleni Bareta  1   2 , Esmeralda Seraj  1   2 , Alexandra Papoudou-Bai  4 , Nicholas Pavlidis  1   2 , Anna Batistatou  4 , George Pentheroudakis  1   2
Affiliations

Extranodal diffuse large B-cell lymphomas: A retrospective case series and review of the literature

Stergios Boussios et al. Hematol Rep. .

Abstract

Non-Hodgkin lymphomas commonly show extranodal involvement (25-30%) but primary diffuse large B-cell lymphomas (DLBCL) with extranodal localization represent clinically and molecularly distinct entities. The present study involved retrospective analysis of case records of 4 patients who were diagnosed with extranodal DLBCL between 2010 and 2016 at the Medical Oncology and Hematology Departments of the Ioannina University Hospital, Greece. Median age of presentation was 69 years (range 60-77 years). There were 2 males and 2 females. The sites of DLBCL involvement included adrenal gland, mandible, cervix uteri, and ileum. Two patients had B symptoms while none had bone marrow involvement. After staging workup, all the patients fell into IE stage. The treatment approach included chemotherapy combined with rituximab (R), whereas one patient received additionally irradiation therapy. Post-treatment positron emission tomography-computed tomography scan was performed in 3 patients. In terms of the outcome, 3 patients are alive in complete response, whereas one was lost in follow-up. Further prospective data analyses are required so as to better elucidate the biology and course of extranodal DLBCL.

Keywords: Chemotherapy; Extranodal; Immunohistochemistry; Lymphomas.

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Conflict of interest statement

Conflict of interest: the authors have declared no potential conflict of interest.

Figures

Figure 1.
Figure 1.
Representative images of morphologic variants of diffuse large B-cell lymphomas in the current study (Hematoxylin and Eosin stain, magnification ×400). Centroblastic (a); Immunoblastic (b).
See this image and copyright information in PMC

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