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. 2019 Oct;269(7):795-802.
doi: 10.1007/s00406-018-0897-z. Epub 2018 May 2.

Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders

Sherif M Gohar  1   2   3 , Ingrid Dieset  4   5 , Nils Eiel Steen  4   5 , Ragni H Mørch  4   5 , Trude S Iversen  4   5 , Vidar M Steen  6   7 , Ole A Andreassen  4   5 , Ingrid Melle  4   5
Affiliations

Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders

Sherif M Gohar et al. Eur Arch Psychiatry Clin Neurosci. 2019 Oct.

Abstract

Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform and schizoaffective disorder (schizophrenia group, n = 344); bipolar I, II, NOS, and psychosis NOS (non-schizophrenia group, n = 308) were recruited consecutively from the Norwegian Thematically Organized Psychosis (TOP) Study. Clinical data were obtained by Positive and Negative Syndrome Scale (PANSS), and Calgary Depression Scale for Schizophrenia (CDSS). Blood samples were analyzed for total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), C-reactive protein (CRP), soluble tumor necrosis factor receptor 1(sTNF-R1), osteoprotegerin (OPG), and interleukin 1 receptor antagonist (IL-1Ra). After adjusting for age, gender, BMI, smoking, and dyslipidemia-inducing antipsychotics, TC and LDL scores showed significant associations with depression [β = 0.13, p = 0.007; β = 0.14, p = 0.007], and with two inflammatory markers: CRP [β = 0.14, p = 0.007; β = 0.16, p = 0.007] and OPG [β = 0.14, p = 0.007; β = 0.11, p = 0.007]. Total model variance was 17% for both analyses [F(12, 433) = 8.42, p < 0.001; F(12, 433) = 8.64, p < 0.001]. Current findings highlight a potential independent role of depression and inflammatory markers, CRP and OPG in specific, in the pathophysiology of dyslipidemia in psychotic disorders.

Keywords: Bipolar; Cholesterol; Cytokines; Depression; Dyslipidemia; Schizophrenia.

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Marginal means in (mmol/L) of total cholesterol (TC), low-density lipoprotein (LDL) and triglyceride (TG) in schizophrenia and non-schizophrenia groups after adjusting for age, sex, BMI, smoking, duration of illness and the use of antipsychotics inducing dyslipidemia. *p < 0.05
See this image and copyright information in PMC

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