[Risks of diabetes mellitus and impaired glucose tolerance induced by intermittent versus continuous androgen-deprivation therapy for advanced prostate cancer]
- PMID: 29723451
[Risks of diabetes mellitus and impaired glucose tolerance induced by intermittent versus continuous androgen-deprivation therapy for advanced prostate cancer]
Abstract
Objective: To investigate the correlation of intermittent androgen-deprivation therapy (IADT) and continuous androgen-deprivation therapy (CADT) for advanced prostate cancer (PCa) with the risks of secondary diabetes mellitus (DM) and impaired glucose tolerance (IGT).
Methods: We conducted a retrospective case-control study of the advanced PCa patients treated by IADT or CADT in our hospital from January 2013 to December 2015. Based on the levels fasting blood glucose and 2-hour postprandial blood glucose, results of oral glucose tolerance test, and clinical symptoms of the patients, we statistically analyzed the IADT- or CADT-related risk factors for DM and IGT and the relationship of the body mass index (BMI), hypertension, smoking, and alcohol consumption with secondary DM and IGT.
Results: IADT was given to 53 (46.5%) of the patients, aged (69.1 ± 4.3) years, and CADT to 61 (53.5%), aged (70.2 ± 5.7) years. No statistically significant differences were observed in clinical characteristics between the two groups of patients (P > 0.05). BMI, blood pressure, smoking and drinking exhibited no significant influence on the development of DM or IGT either in the IADT (P > 0.05) or the CADT group. The incidence of IGT was significantly lower in the IADT than in the CADT group (P = 0.03), but that of DM showed no statistically significant difference between the two groups (P = 0.64).
Conclusions: Compared with CADT, IADT has a lower risk of IGT and a higher safety in the treatment of advanced prostate cancer.
目的： 探讨晚期前列腺癌间歇性雄激素剥夺治疗(IADT)和持续性雄激素剥夺治疗(CADT)两种不同方式与继发糖尿病(DM)和糖耐量异常（IGT）风险的相关性。方法： 对2013年1月至2015年12月于我院进行雄激素剥夺治疗(ADT)的PCa患者进行回顾性病例对照研究。通过监测患者空腹血糖、餐后2 h血糖及口服糖耐量试验，结合患者相关临床症状，对IADT和CADT引起DM和IGT的风险进行统计学分析，并分析组内体质量指数（BMI）、高血压、吸烟、饮酒等因素与继发性DM和IGT的关系。结果： IADT组53例(46.5%)，平均(69.1±4.3)岁；CADT组61例(53.5%)，平均(70.2±5.7)岁，两组在临床特点方面均无明显差异(P均>0.05)；IADT组BMI、高血压、吸烟、饮酒等因素对DM、IGT的发生均无明显影响(P均>0.05)，CADT组BMI、高血压、吸烟、饮酒因素对DM、IGT的发生均无明显影响（P均>0.05）；IADT组与CADT组比较，DM的发生无统计学意义（P=0.64）；但IGT的发生有统计学意义（P= 0.03）。结论： IADT 与CADT比较，PCa患者的IGT发生风险更低，安全性更高。.
Keywords: continuous androgen-deprivation therapy; diabetes mellitus; impaired glucose tolerance; intermittent androgen-deprivation therapy; prostate cancer.