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. 2018 May 16;140(19):6062-6066.
doi: 10.1021/jacs.8b03560. Epub 2018 May 4.

Rhodium-Catalyzed, Remote Terminal Hydroarylation of Activated Olefins through a Long-Range Deconjugative Isomerization

Arun Jyoti Borah  1 , Zhuangzhi Shi  1
Affiliations

Rhodium-Catalyzed, Remote Terminal Hydroarylation of Activated Olefins through a Long-Range Deconjugative Isomerization

Arun Jyoti Borah et al. J Am Chem Soc. .

Abstract

The Rh-catalyzed, remote terminal hydroarylation of active olefins at the C7-position of indoles and the ortho-position of indolines and anilines with the appropriate choice of a N-P tBu2 directing group through long-range deconjugative isomerization has been reported. This transformation not only overcomes the conjugate rule of Michael acceptors but also controls the positional selectivity of indoles, representing a significant advancement in both alkene isomerization and the C-H alkylation of indoles.

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