Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;51(6):1946-8.
doi: 10.1111/j.1471-4159.1988.tb01183.x.

Systemic lipopolysaccharide and pokeweed mitogen increase quinolinic acid content of mouse cerebral cortex

M P Heyes  1 , P Kim, S P Markey
Affiliations

Systemic lipopolysaccharide and pokeweed mitogen increase quinolinic acid content of mouse cerebral cortex

M P Heyes et al. J Neurochem. 1988 Dec.

Abstract

The effects of lipopolysaccharide and pokeweed mitogen on brain L-tryptophan and quinolinic acid (QUIN) concentrations were investigated in C57BL/6NCR mice. Twenty-four hours after an intraperitoneal injection of lipopolysaccharide (5 micrograms from Salmonella abortus equii) or pokeweed mitogen (500 micrograms), cortical QUIN concentrations were increased by 81 +/- 6% and 182 +/- 15%, respectively. Plasma QUIN was increased 175 +/- 7% of control in pokeweed-mitogen treated mice only. Brain L-tryptophan concentrations were increased, whereas plasma L-tryptophan concentrations were decreased. The consequences of increased QUIN concentrations during endotoxin and mitogen exposure remain to be determined.

PubMed Disclaimer

LinkOut - more resources