Electropolymerized hydrophilic coating on stainless steel for biomedical applications

Abstract

Current metal implants (e.g. stents) covered with drug-eluting coatings are not robust for long-term usage. Other types and methods of coatings are needed, especially ones that are not prone to activity loss in vivo. In this paper, the method of stainless steel (SS) coating with poly(ethylene glycol) dimethacrylate (PEGDMA) with the use of electropolymerization (EP) is presented. The application of a specific and simple reaction mixture enabled the production of SS-PEGDMA materials that possessed a homogenous surface. The polymer coating was durable for 28 days of constant washing. The resulting materials were non-toxic and haemolysis did not occur after incubation with blood. Moreover, because the coating filled up scratches present on bare SS and hydrophilized the SS surface, it reduced fibrinogen adsorption five times in comparison to SS and, unlike on SS, no platelet activation was detected. The presented method is a very promising candidate for scale up due to its simplicity and low cost.

Keywords: Biocompatibility; Electropolymerization; Hemocompatibility; Polymer coating; Stainless steel 316L.