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. 2018 Nov 5;28(11):465-469.
doi: 10.2188/jea.JE20170093. Epub 2018 May 4.

Cumulative Risk of Type 2 Diabetes in a Working Population: The Japan Epidemiology Collaboration on Occupational Health Study

Huanhuan Hu  1 , Tohru Nakagawa  2 , Hiroko Okazaki  3 , Chihiro Nishiura  4 , Teppei Imai  5 , Toshiaki Miyamoto  6 , Naoko Sasaki  7 , Makoto Yamamoto  8 , Taizo Murakami  9 , Takeshi Kochi  10 , Masafumi Eguchi  10 , Kentaro Tomita  11 , Satsue Nagahama  12 , Keisuke Kuwahara  1   13 , Isamu Kabe  10 , Tetsuya Mizoue  1 , Seitaro Dohi  3
Affiliations

Cumulative Risk of Type 2 Diabetes in a Working Population: The Japan Epidemiology Collaboration on Occupational Health Study

Huanhuan Hu et al. J Epidemiol. .

Abstract

Background: We estimated the cumulative risk of type 2 diabetes from age 30 to 65 years in a large working population in Japan.

Methods: We used data from the Japan Epidemiology Collaboration on Occupational Health Study. Participants (46,065 men and 7,763 women) were aged 30-59 years, free of diabetes at baseline, and followed up for a maximum of 7 years. Incident type 2 diabetes was defined based on fasting and casual glucose, glycated hemoglobin, and current medical treatment for type 2 diabetes. We calculated the sex-specific cumulative risk of type 2 diabetes using the Practical Incidence Estimator macro, which was created to produce several estimates of disease incidence for prospective cohort studies based on a modified Kaplan-Meier method.

Results: During 274,349 person-years of follow-up, 3,587 individuals (3,339 men and 248 women) developed type 2 diabetes. The cumulative risk was 34.7% (95% confidence interval, 33.1-36.3%) for men and 18.6% (95% confidence interval, 15.5-21.7%) for women. In BMI-stratified analysis, obese (BMI ≥30 kg/m2) and overweight (BMI 25-29.9 kg/m2) men and women had a much higher cumulative risk of type 2 diabetes (obese: 77.3% for men and 64.8% for women; overweight: 49.1% and 35.7%, respectively) than those with BMI <25 kg/m2 (26.2% and 13.4% for men and women, respectively).

Conclusions: The present data highlight the public health burden of type 2 diabetes in the working population. There is a need for effective programs for weight management and type 2 diabetes screening, especially for young obese employees, to prevent or delay the development of type 2 diabetes.

Keywords: Japanese; cumulative risk; epidemiology; type 2 diabetes.

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Figures

Figure 1.
Figure 1.. Cumulative risk of diabetes in individuals aged 30 years. A. Overall; B. BMI <25 kg/m2; C. BMI 25–29.9 kg/m2; D. BMI ≥30 kg/m2.
See this image and copyright information in PMC

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