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Review
. 2018 Mar;10(Suppl 5):S642-S652.
doi: 10.21037/jtd.2017.11.02.

Drugs pharmacokinetics during veno-venous extracorporeal membrane oxygenation in pediatrics

Matteo Di Nardo  1 , Enno Diederick Wildschut  2
Affiliations
Review

Drugs pharmacokinetics during veno-venous extracorporeal membrane oxygenation in pediatrics

Matteo Di Nardo et al. J Thorac Dis. 2018 Mar.

Abstract

Data evaluating pharmacokinetic/pharmacodynamic (PK/PD) aspect in the pediatric population are scarce especially regarding the pediatric intensive care unit. Dosing of frequently used drugs (sedatives, analgesics, antibiotics and cardiovascular drugs) are mainly based on non "pediatric intensive care unit (PICU)" patients, and sometimes are translated from adult patients. Among PICU patients, the most complex patients are the ones who are critically ill and are receiving mechanical circulatory/respiratory support for cardiac and/or respiratory failure. The use of extracorporeal membrane oxygenation is associated with major PK and PD changes, especially in neonates and children. The objective of this review is to assess the current literature for pediatric PK data in patients receiving extracorporeal membrane oxygenation (ECMO).

Keywords: Pediatric; extracorporeal membrane oxygenation (ECMO); pharmacodynamics (PD); pharmacokinetics (PKs).

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

References

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