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Comment
. 2018 Jun 1;128(6):2197-2198.
doi: 10.1172/JCI121080. Epub 2018 May 7.

A viral protein kinase drug target for tumors?

Richard F Ambinder
Comment

A viral protein kinase drug target for tumors?

Richard F Ambinder. J Clin Invest. .

Abstract

The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Expression of the KSHV protein kinase in transgenic mice under the control of a ubiquitin promoter was associated with B cell lymphoproliferative disease and lymphoma. If the viral protein kinase is important in the pathogenesis of KSHV lymphoproliferative disease or lymphoma, the kinase may present a very good target for pharmacologic therapies.

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Conflict of interest statement

Conflict of interest: The author has declared that no conflict of interest exists.

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