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Review
. 2018 May 7;11(2):42.
doi: 10.3390/ph11020042.

2017 FDA Peptide Harvest

Othman Al Musaimi  1   2 , Danah Al Shaer  3   4 , Beatriz G de la Torre  5 , Fernando Albericio  6   7   8
Affiliations
Review

2017 FDA Peptide Harvest

Othman Al Musaimi et al. Pharmaceuticals (Basel). .

Abstract

2017 was an excellent year in terms of new drugs (chemical entities and biologics) approved by the FDA, with a total of 46. In turn, one of the highlights was the number of peptides (six) included in this list. Here, the six peptides are analyzed in terms of chemical structure, synthetic strategy used for their production, source, therapeutic use, and mode of action.

Keywords: drug discovery; drugs; pharmaceutical market; solid-phase peptide synthesis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
New drugs approved by the FDA in 2017 and classified on the basis of chemical structure.
Figure 2
Figure 2
Structure of (a) plecanatide and (b) the related linaclotide.
Figure 3
Figure 3
Structure of etelcalcetide. Amino acids of D configuration are shown in red.
Figure 4
Figure 4
Structure of (a) abaloparatide and (b) teriparatide. The residues modified are shown in red. The non-proteinogenic amino acid Aib is shown in bold.
Figure 5
Figure 5
Structure of (a) semaglutide and (b) its related liraglutide. Changes in structure with respect to GLP-1 (7-37) are shown in color.
Figure 6
Figure 6
Structure of macimorlein. Modifications with respect to a tripeptide are shown in red.
Figure 7
Figure 7
Structure of angiotensin II.
See this image and copyright information in PMC

References

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