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Review
. 2018 Jan 28:10:37-44.
doi: 10.1016/j.ensci.2018.01.007. eCollection 2018 Mar.

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis

Matin Khosravi-Largani  1 , Parmida Pourvali-Talatappeh  1 , Ali Mohammad Rousta  1 , Maedeh Karimi-Kivi  1 , Elahe Noroozi  1 , Ali Mahjoob  1 , Yasaman Asaadi  2 , Alireza Shahmohammadi  1 , Sarina Sadeghi  1 , Shiva Shakeri  1 , Kimiya Ghiyasvand  1 , Masoumeh Tavakoli-Yaraki  3
Affiliations
Review

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis

Matin Khosravi-Largani et al. eNeurologicalSci. .

Abstract

Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease, with unknown etiology. Vitamins, as important micronutrients playing different roles in body, seem to be important in MS pathogenesis. In vitro, in vivo and human studies, supports the protective role of some vitamins in MS occurrence or progression. Current study reviews recent insights and reports about the importance of vitamins in MS incidence or progression. In accordance, the importance of all water and fat-soluble vitamins in MS pathogenesis based on observational studies in human population and their role in the function of immune system as well as possible therapeutic opportunities are discussed in depth throughout this review.

Keywords: Experimental autoimmune encephalomyelitis; Folic acid; Multiple sclerosis; Vitamin A; Vitamin B 12; Vitamin D; Vitamin E; Vitamins.

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