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. 2018 Mar;27(3):515-519.
doi: 10.1177/0963689717753187. Epub 2018 May 8.

Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation

Tang-Her Jaing  1   2 , Shih-Hsiang Chen  1   2 , Yu-Chuan Wen  3 , Tsung-Yen Chang  1   2 , Ya-Chun Yang  3 , Pei-Kwei Tsay  2   4
Affiliations

Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation

Tang-Her Jaing et al. Cell Transplant. 2018 Mar.

Abstract

Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48%). There was no significant association between cryopreservation duration and neutrophil engraftment probability ( P = 0.475). Cryopreservation duration did not affect the post-thaw viability and subsequent neutrophil engraftment rate. Therefore, UCB units can undergo cryopreservation for at least 8 y with no impact on clinical outcomes.

Keywords: cryopreservation; transplantation; umbilical cord blood.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Fig. 1.
Fig. 1.
Umbilical cord blood units (CBUs) by duration of cryopreservation. A total of 32 CBUs were cryopreserved for >8 y.
See this image and copyright information in PMC

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