Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Feb 15;36(4):639.
doi: 10.1089/neu.2018.5847. Epub 2018 Jul 5.

mtROS-Induced TRPV4 Activation in Traumatic Brain Injury

Karthik Suresh  1
Affiliations
Comment

mtROS-Induced TRPV4 Activation in Traumatic Brain Injury

Karthik Suresh. J Neurotrauma. .
No abstract available

PubMed Disclaimer

Comment on

References

    1. Szarka N., Pabbidi M.R., Amrein K., Czeiter E., Berta G., Pohoczky K., Helyes Z., Ungvari Z., Koller A., Buki A., and Toth P. (2018). Traumatic brain injury impairs myogenic constriction of cerebral arteries: role of mitochondria-derived H2O2 and TRPV4-dependent activation of BKCa channels. J Neurotrauma 35, 930–939 - PMC - PubMed
    1. Suresh K., Servinsky L., Jiang H., Bigham Z., Yun X., Kliment C., Huetsch J.C., Damarla M., and Shimoda L.A. (2018). Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension. Am. J. Physiol. Lung. Cell. Mol. Physiol. 5, 893–907 - PMC - PubMed
    1. Suresh K., Servinsky L., Reyes J., Baksh S., Undem C., Caterina M., Pearse D.B., and Shimoda L.A. (2015). Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4. Am. J. Physiol. Lung Cell Mol. Physiol. 309, L1467–L1477 - PMC - PubMed
    1. Thorneloe K.S., Cheung M., Bao W., Alsaid H., Lenhard S., Jian M.Y., Costell M., Maniscalco-Hauk K., Krawiec J.A., Olzinski A., Gordon E., Lozinskaya I., Elefante L., Qin P., Matasic D.S., James C., Tunstead J., Donovan B., Kallal L., Waszkiewicz A., Vaidya K., Davenport E.A., Larkin J., Burgert M., Casillas L.N., Marquis R.W., Ye G., Eidam H.S., Goodman K.B., Toomey J.R., Roethke T.J., Jucker B.M., Schnackenberg C.G., Townsley M.I., Lepore J.J., and Willette R.N. An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci. Transl. Med. 4, 159ra148 - PubMed
    1. Dong Q., Li J., Wu Q.F., Zhao N., Qian C., Ding D., Wang B.B., Chen L., Guo K.F., Fu D., Han B., Liao Y.H., and Du Y.M. (2017). Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice. Sci. Rep. 7, 42678. - PMC - PubMed

LinkOut - more resources