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. 1988 Nov;39(5):511-8.
doi: 10.4269/ajtmh.1988.39.511.

Failure of a dengue 1 sub-unit vaccine to protect mice against a lethal dengue virus infection

J G Aaskov  1 , L Williams, J Fletcher, R Hay
Affiliations

Failure of a dengue 1 sub-unit vaccine to protect mice against a lethal dengue virus infection

J G Aaskov et al. Am J Trop Med Hyg. 1988 Nov.

Abstract

Mice immunized with DEN-1 pre-matrix protein produced antibody which reacted with dengue virus infected cells and intact virions but failed to neutralize virus in vitro or in vivo. Newborn mice passively immunized with anti-DEN-1 pre-matrix antibody also failed to survive intracerebral infection with 100 LD50 of any dengue virus serotype.

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