Beta-elemene increases chemosensitivity to 5-fluorouracil through down-regulating microRNA-191 expression in colorectal carcinoma cells
- PMID: 29737579
- DOI: 10.1002/jcb.26914
Beta-elemene increases chemosensitivity to 5-fluorouracil through down-regulating microRNA-191 expression in colorectal carcinoma cells
Retraction in
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Retraction.J Cell Biochem. 2021 Jun;122(6):690. doi: 10.1002/jcb.29901. Epub 2021 Feb 2. J Cell Biochem. 2021. PMID: 33901309
Abstract
Colorectal carcinoma is a common malignant tumor occurring in the alimentary system. Despite developments of modern medicine, developed resistance to 5-fluorouracil (5-FU) may lead to poor prognosis. Herein, we aimed to explore the effects of beta-elemene on colorectal carcinoma cells (HCT116 and HT29) as well as the underlying mechanisms. Beta-elemene reduced cell viability and induced apoptosis in HCT116 and HT29 cells. Increased apoptosis following beta-elemene exposure was due to enhanced sensitivity to 5-FU through down-regulating miR-191. Expression of key kinases, including Wnt3a, and β-catenin, were down-regulated by beta-elemene through a miR-191 mechanism. Moreover, beta-elemene might improve resistance of colorectal carcinoma cells to 5-FU by down-regulating miR-191, thereby inhibiting the Wnt/β-catenin pathway.
Keywords: Wnt/β-catenin; apoptosis; beta-elemene; colorectal carcinoma; microRNA-191; viability.
© 2018 Wiley Periodicals, Inc.
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