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Comment
. 2018 May 8;19(1):57.
doi: 10.1186/s13059-018-1433-1.

The hypothesis of ultraconserved enhancer dispensability overturned

Laura Elnitski  1 , Ivan Ovcharenko  2
Affiliations
Comment

The hypothesis of ultraconserved enhancer dispensability overturned

Laura Elnitski et al. Genome Biol. .

Abstract

Two recent studies explore how redundant enhancers in mice really are.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Pairwise deletion of redundant ultraconserved elements in the locus of the mouse Arx gene [4] (a, b) and redundant strongly conserved enhancers of the mouse Gli3 gene [8] (c). A combined deletion of two dorsal forebrain enhancers hs122 and hs123 leads to a smaller dentate gyrus (white staining) with disorganized appearance (a). A combined deletion of two ventral forebrain enhancers hs119 and hs121 leads to a drastic decrease in the density of striatal cholinergic neuron density (b). A combined deletion of two Gli3 limb enhancers in a sensitized genetic background leads to a severe polydactyly (c). ChAT choline acetyltransferase, UCE ultraconserved element
See this image and copyright information in PMC

Comment on

  • Ultraconserved Enhancers Are Required for Normal Development.
    Dickel DE, Ypsilanti AR, Pla R, Zhu Y, Barozzi I, Mannion BJ, Khin YS, Fukuda-Yuzawa Y, Plajzer-Frick I, Pickle CS, Lee EA, Harrington AN, Pham QT, Garvin TH, Kato M, Osterwalder M, Akiyama JA, Afzal V, Rubenstein JLR, Pennacchio LA, Visel A. Dickel DE, et al. Cell. 2018 Jan 25;172(3):491-499.e15. doi: 10.1016/j.cell.2017.12.017. Epub 2018 Jan 18. Cell. 2018. PMID: 29358049 Free PMC article.
  • Enhancer redundancy provides phenotypic robustness in mammalian development.
    Osterwalder M, Barozzi I, Tissières V, Fukuda-Yuzawa Y, Mannion BJ, Afzal SY, Lee EA, Zhu Y, Plajzer-Frick I, Pickle CS, Kato M, Garvin TH, Pham QT, Harrington AN, Akiyama JA, Afzal V, Lopez-Rios J, Dickel DE, Visel A, Pennacchio LA. Osterwalder M, et al. Nature. 2018 Feb 8;554(7691):239-243. doi: 10.1038/nature25461. Epub 2018 Jan 31. Nature. 2018. PMID: 29420474 Free PMC article.

References

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    1. Dickel DE, Ypsilanti AR, Pla R, Zhu Y, Barozzi I, Mannion BJ, et al. Ultraconserved enhancers are required for normal development. Cell. 2018;172:491–9.e15. doi: 10.1016/j.cell.2017.12.017. - DOI - PMC - PubMed
    1. Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch RV, et al. A high-resolution enhancer atlas of the developing telencephalon. Cell. 2013;152:895–908. doi: 10.1016/j.cell.2012.12.041. - DOI - PMC - PubMed

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