Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;81(1):38-40.
doi: 10.1007/BF00283726.

Increased methotrexate-induced chromosome breakage in patients with free trisomy 21 and their parents

L Pelz  1 , J Götz, G Krüger, G Witt
Affiliations

Increased methotrexate-induced chromosome breakage in patients with free trisomy 21 and their parents

L Pelz et al. Hum Genet. 1988 Dec.

Abstract

Increased susceptibility of chromosomes from peripheral blood lymphocytes to the antimetabolite methotrexate (2 X 10(-6) M) has been found in patients with free trisomy 21 and their parents (N = 14). The level of induced chromatid and chromosome breaks is lowest in normal controls intermediate in patients' mothers and fathers, and highest in trisomy 21 patients. The findings are viewed as a special type of cytogenetic polymorphism or as a defective chromosomal infrastructure, also in the parents of trisomic children.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Hum Genet. 1980;56(1):123-5 - PubMed
    1. Mutat Res. 1977 Jun;43(3):401-13 - PubMed
    1. Humangenetik. 1972;16(4):329-36 - PubMed
    1. Am J Hum Genet. 1980 Jul;32(4):477-83 - PubMed
    1. Ann Hum Genet. 1976 Jan;39(3):293-303 - PubMed

LinkOut - more resources