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. 1988 Dec;81(1):38-40.
doi: 10.1007/BF00283726.

Increased methotrexate-induced chromosome breakage in patients with free trisomy 21 and their parents

L Pelz  1 , J Götz, G Krüger, G Witt
Affiliations

Increased methotrexate-induced chromosome breakage in patients with free trisomy 21 and their parents

L Pelz et al. Hum Genet. 1988 Dec.

Abstract

Increased susceptibility of chromosomes from peripheral blood lymphocytes to the antimetabolite methotrexate (2 X 10(-6) M) has been found in patients with free trisomy 21 and their parents (N = 14). The level of induced chromatid and chromosome breaks is lowest in normal controls intermediate in patients' mothers and fathers, and highest in trisomy 21 patients. The findings are viewed as a special type of cytogenetic polymorphism or as a defective chromosomal infrastructure, also in the parents of trisomic children.

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