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. 2018 May;25(4):715-718.
doi: 10.1016/j.sjbs.2017.12.002. Epub 2017 Dec 5.

Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats

Xuejun Kong  1 , Yanling Gao  1 , Xiuli Geng  1 , Guoqi Xie  1 , Shaojun Hao  1 , Yan Li  1 , Zhengchen Zhang  1
Affiliations

Effect of lipid lowering tablet on blood lipid in hyperlipidemia model rats

Xuejun Kong et al. Saudi J Biol Sci. 2018 May.

Abstract

Observe the effect of lipid-lowering tablets on body weight, liver index and serum biochemical indexes of hyperlipidemia rats. The hyperlipidemia rat model was replicated successfully. Compared with the model group, high, medium and low dose lipid-lowering tablets group could significantly increase the body weight of rats with hyperlipidemia (P < 0.01, P < 0.05); High and middle dose lipid-lowering tablets group could significantly reduce the liver index of high fat rat (P < 0.01); High, medium and low dose lipid-lowering tablets group could significantly decrease levels of TC, TG, LDL-C, AST, ALT, ALP, Y-GT in serum (P < 0.01, P < 0.05), and significantly increase the level of HDL-C (P < 0.01). Lipid-lowering tablets can effectively regulate the body lipid metabolism of rats, and have a certain therapeutic effect on hyperlipidemia.

Keywords: Body weight; Hyperlipidemia; Lipid-lowering tablet; Liver index; Rats; Serum biochemical index.

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