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. 2018 Oct;41(10):1579-1589.
doi: 10.1007/s00270-018-1982-4. Epub 2018 May 8.

Radioembolisation in Europe: A Survey Amongst CIRSE Members

Affiliations

Radioembolisation in Europe: A Survey Amongst CIRSE Members

Margot T M Reinders et al. Cardiovasc Intervent Radiol. 2018 Oct.

Abstract

Introduction: Radioembolisation of liver tumours demands many choices from the physician regarding planning of treatment and subsequent follow-up.

Methods: An online questionnaire was distributed amongst all members of the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) to investigate the current state of radioembolisation practice.

Results: The survey was completed by 60 centres. The increasing number of radioembolisation procedures may reflect that radioembolisation is increasingly recognised as a valuable treatment option in European cancer guidelines. Imaging modalities play an important role in decision making. Furthermore, there seems to be a trend towards less coil-embolisation of non-target vessels. In addition, type of microsphere, model for dose calculation, complications and future developments are evaluated in this article.

Conclusions: This survey provides insight into the current state of radioembolisation practice across Europe.

Keywords: Interventional oncology; Liver; Radioembolisation; Yttrium.

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Conflict of interest statement

Conflict of interest

The Department of Radiology and Nuclear Medicine of the UMCU receives royalties and research support from Quirem Medical and Terumo. Marnix Lam is a consultant for BTG, Terumo and Quirem Medical. Maarten Smits has served as a speaker for Sirtex Medical and Terumo. All other authors declare to have no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Figures

Fig. 1
Fig. 1
A Geographical representation of number of radioembolisation procedures per centre in 2016 (Q3). B Geographical representation of the type of microspheres used in the 60 participating centres (Q5)
Fig. 2
Fig. 2
Number of centres starting to perform radioembolisation per year. Please note that these numbers only represent the centres that participated in this survey and one centre did not answer this question (Q2)
Fig. 3
Fig. 3
Heat map representing number of patients per tumour type per centre per year (Q4)
Fig. 4
Fig. 4
Pie charts regarding imaging techniques used in radioembolisation treatment (Q6a, Q8, Q9, Q19, Q20 and Q22)
Fig. 5
Fig. 5
Heat map of the conditions that centres marked as a contraindication or not (Q7)
Fig. 6
Fig. 6
Percentage of centres that exclude and/or reduce dose in patients due to lung shunting (Q11 and Q12)
Fig. 7
Fig. 7
Heat map of frequency of arteries that are coiled by participating centres (Q14)
Fig. 8
Fig. 8
Number of centres that prescribe certain medication in pretreatment, during treatment and post-treatment (Q15)
Fig. 9
Fig. 9
Heat map representing number of centres that encounter complications per patient category (Q23)
Fig. 10
Fig. 10
Heat map on future perspectives (Q24)

References

    1. Ahmadzadehfar H, Biersack HJ, Ezziddin S. Radioembolization of liver tumors with yttrium-90 microspheres. Semin Nucl Med. 2010;40(2):105–121. doi: 10.1053/j.semnuclmed.2009.11.001. - DOI - PubMed
    1. Dezso K, Bugyik E, Papp V, Laszlo V, Dome B, Tovari J, et al. Development of arterial blood supply in experimental liver metastases. Am J Pathol. 2009;175(2):835–843. doi: 10.2353/ajpath.2009.090095. - DOI - PMC - PubMed
    1. Salem R, Mazzaferro V, Sangro B. Yttrium 90 radioembolization for the treatment of hepatocellular carcinoma: biological lessons, current challenges, and clinical perspectives. Hepatology. 2013;58(6):2188–2197. doi: 10.1002/hep.26382. - DOI - PMC - PubMed
    1. Powerski MJ, Scheurig-Munkler C, Banzer J, Schnapauff D, Hamm B, Gebauer B. Clinical practice in radioembolization of hepatic malignancies: a survey among interventional centres in Europe. Eur J Radiol. 2012;81(7):e804–e811. doi: 10.1016/j.ejrad.2012.04.004. - DOI - PubMed
    1. van den Hoven AF, Prince JF, de Keizer B, Vonken EJ, Bruijnen RC, Verkooijen HM, et al. Use of C-arm cone beam CT during hepatic radioembolization: protocol optimization for extrahepatic shunting and parenchymal enhancement. Cardiovasc Intervent Radiol. 2016;39(1):64–73. doi: 10.1007/s00270-015-1146-8. - DOI - PMC - PubMed