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. 2018 May 30;140(21):6545-6549.
doi: 10.1021/jacs.8b03509. Epub 2018 May 17.

Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

Peng-Xiang Shen  1 , Liang Hu  1 , Qian Shao  1 , Kai Hong  1 , Jin-Quan Yu  1
Affiliations

Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

Peng-Xiang Shen et al. J Am Chem Soc. .

Abstract

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

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Figures

Scheme 1
Scheme 1
Bidentate Ligands Developed for Enantioselective C(sp3)–H Functionalization of Carboxylic Acids
See this image and copyright information in PMC

References

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