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Meta-Analysis
. 2018 May;97(19):e0719.
doi: 10.1097/MD.0000000000010719.

Association between obesity with disease-free survival and overall survival in triple-negative breast cancer: A meta-analysis

Lin Mei  1 , Lin He, Yuhua Song, Yang Lv, Lijiu Zhang, Fengxi Hao, Mengmeng Xu
Affiliations
Meta-Analysis

Association between obesity with disease-free survival and overall survival in triple-negative breast cancer: A meta-analysis

Lin Mei et al. Medicine (Baltimore). 2018 May.

Abstract

Objective: To investigate the relationship between obesity and disease-free survival (DFS) and overall survival (OS) of triple-negative breast cancer.

Methods: Citations were searched in PubMed, Cochrane Library, and Web of Science. Random effect model meta-analysis was conducted by using Revman software version 5.0, and publication bias was evaluated by creating Egger regression with STATA software version 12.

Results: Nine studies (4412 patients) were included for DFS meta-analysis, 8 studies (4392 patients) include for OS meta-analysis. There were no statistical significances between obesity with DFS (P = .60) and OS (P = .71) in triple-negative breast cancer (TNBC) patients.

Conclusion: Obesity has no impact on DFS and OS in patients with TNBC.

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Conflict of interest statement

Compliance with Ethical Standards: The authors have no potential conflicts of interest in this manuscript, and this article does not contain any studies with human participants or animals performed by any of the authors.

Figures

Figure 1
Figure 1
The process of the study selection. DFS = disease-free survival, OS = overall survival.
Figure 2
Figure 2
The relationship between obesity and no-obesity for overall survival (OS). CI = confidence interval.
Figure 3
Figure 3
The subgroup analysis in the relationship between obesity and no-obesity for overall survival (OS). CI = confidence interval.
Figure 4
Figure 4
The relationship between obesity and no-obesity for DFS.
Figure 5
Figure 5
The subgroup analysis in relationship between obesity with no-obesity for disease-free survival (DFS). CI = confidence interval.
See this image and copyright information in PMC

References

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