Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Mar 25;6(5):915-916.
doi: 10.1002/ccr3.1436. eCollection 2018 May.

A typical atypical chronic myeloid leukemia

Andrea Gilioli  1 , Ambra Paolini  1 , Goretta Bonacorsi  1 , Mario Luppi  1
Affiliations
Case Reports

A typical atypical chronic myeloid leukemia

Andrea Gilioli et al. Clin Case Rep. .

Abstract

In the context of leukocytosis due to increased number of neutrophils and their precursors, with significant dysgranulopoiesis and no or minimal basophilia and no or minimal monocytosis, the typical feature of "clumped" chromatin, in irregularly coarse compacted nuclei, should lead to suspect the diagnosis of atypical chronic myeloid leukemia.

Keywords: aCML; clinical case; hematology; leukocytosis; peripheral blood smear.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Peripheral blood smear, May‐Grünwald Giemsa stain, 600x. In detail: medium‐sized myeloblasts, promonocytes, and atypical neutrophils with a characteristic “clumped” chromatin, in irregularly compacted nuclei, and hypergranular cytoplasm can be noticed.
Figure 2
Figure 2
Peripheral blood smear, May‐Grünwald Giemsa stain, 1000x. Detail of atypical neutrophils with a characteristic “clumped” chromatin, in irregularly compacted nuclei, and hypergranular cytoplasm.
Figure 3
Figure 3
Bone marrow trephine biopsy, hematoxylin and eosin stain, 200x. In detail: an extremely hypercellular bone marrow, with intense granulocytic hyperplasia showing dysplastic maturation, can be seen.
See this image and copyright information in PMC

References

    1. Arber, D. A. , Orazi A., Hasserjian R., Thiele J., Borowitz M. J., Le Beau M. M., et al. 2016. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127:2391–2405. - PubMed

Publication types

LinkOut - more resources