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. 2018 Apr 3;3(3):218-224.
doi: 10.1016/j.bioactmat.2018.03.003. eCollection 2018 Sep.

Antibacterial forsterite (Mg2SiO4) scaffold: A promising bioceramic for load bearing applications

Rajan Choudhary  1 , Ankita Chatterjee  2 , Senthil Kumar Venkatraman  1 , Sivasankar Koppala  3 , Jayanthi Abraham  2 , Sasikumar Swamiappan  1
Affiliations

Antibacterial forsterite (Mg2SiO4) scaffold: A promising bioceramic for load bearing applications

Rajan Choudhary et al. Bioact Mater. .

Erratum in

Abstract

In the current work, forsterite samples with different surface area were investigated for its antibacterial activity. Dissolution studies show that the lower degradation of forsterite compared to other silicate bioceramics, which is a desirable property for repairing bone defects. Forsterite scaffold shows superior compressive strength than the cortical bone after immersion in simulated body fluid. Bactericidal tests indicate that the forsterite had inhibition effect on the growth of clinical bacterial isolates. Forsterite may be a suitable candidate material for load bearing applications with enhanced mechanical properties and lower degradation rate.

Keywords: Antibacterial; Bone; Dissolution; Magnesium silicate; Mechanical stability.

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Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
XRD pattern of forsterite samples after sintering.
Fig. 2
Fig. 2
SEM micrographs of FG (a), FU (c) and EDX pattern of FG (b), FU (d) samples.
Fig. 3
Fig. 3
Degradation behavior (a) compressive strength (b) and Young's modulus (c) of forsterite samples after 30 days of immersion in SBF.
Fig. 4
Fig. 4
Percentage inhibition of different clinical pathogens by pure forsterite (FG and FU).
Fig. 5
Fig. 5
Growth of S. aureus on (a) control, (b) FG 2 mg/mL, (c) FU 2 mg/mL; The growth of E. Coli on (d) control, (e) FG 2 mg/mL and (f) FU 2 mg/mL in agar medium.
Fig. 6
Fig. 6
SEM micrographs of forsterite samples after antibacterial studies; Control E. coli (a), FG E. coli (b), FU E. coli (c), Control S. aureus (d), FG S. aureus (e), FU S. aureus (f).
See this image and copyright information in PMC

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