What Makes a Great Medicinal Chemist? A Personal Perspective

Abstract

Although it is extremely challenging to invent new medicines, I have observed that certain behaviors seem to be commonly found among successful medicinal chemists. Those who exhibit most of these character traits are far more likely to bring new drugs into the clinic and onto the market. And, importantly, organizations that encourage these behaviors are far more likely to be successful. These traits can be broken into two categories: "general" and "discipline-specific". General traits are those that are common to all great scientists, while the discipline-specific ones are more specialized behaviors relevant to the medicinal chemistry enterprise. I describe these traits, and include some specific examples for each of the medicinal chemistry characteristics that I hope will be illustrative. While success in drug discovery is never guaranteed, I believe that embracing and encouraging these behaviors increase the probability of a successful outcome.