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Comment
. 2018 Sep 15;24(18):4352-4354.
doi: 10.1158/1078-0432.CCR-18-0969. Epub 2018 May 10.

Clonal Hematopoiesis: A New Layer in the Liquid Biopsy Story in Lung Cancer

Joshua Bauml  1 , Benjamin Levy  2
Affiliations
Comment

Clonal Hematopoiesis: A New Layer in the Liquid Biopsy Story in Lung Cancer

Joshua Bauml et al. Clin Cancer Res. .

Abstract

Cell-free DNA (cfDNA) is a unique biospecimen that contains multiple sources of DNA, including tumor, germline, fetal, and others. Clonal hematopoiesis, a process that leads to expansion of mutations in peripheral blood cells, is an additional source of DNA that adds a layer of complexity when interpreting results. Clin Cancer Res; 24(18); 4352-4. ©2018 AACRSee related article by Hu et al., p. 4437.

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  • False-Positive Plasma Genotyping Due to Clonal Hematopoiesis.
    Hu Y, Ulrich BC, Supplee J, Kuang Y, Lizotte PH, Feeney NB, Guibert NM, Awad MM, Wong KK, Jänne PA, Paweletz CP, Oxnard GR. Hu Y, et al. Clin Cancer Res. 2018 Sep 15;24(18):4437-4443. doi: 10.1158/1078-0432.CCR-18-0143. Epub 2018 Mar 22. Clin Cancer Res. 2018. PMID: 29567812

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