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Comment
. 2018 Jun;29(6):1590-1592.
doi: 10.1681/ASN.2018040402. Epub 2018 May 10.

Does the Receipt of Antibiotics for Common Infectious Diseases Predispose to Kidney Stones? A Cautionary Note for All Health Care Practitioners

Lama Nazzal  1 , Martin J Blaser  2   3
Affiliations
Comment

Does the Receipt of Antibiotics for Common Infectious Diseases Predispose to Kidney Stones? A Cautionary Note for All Health Care Practitioners

Lama Nazzal et al. J Am Soc Nephrol. 2018 Jun.
No abstract available

Keywords: antibiotics; kidney stones; microbiome; nephrolithiasis.

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Figures

Figure 1.
Figure 1.
Proposed model linking antibiotic exposures to heightened kidney stone risk. The intestinal microbiota contains multiple species that, by their actions on dietary constituents and mucosal epithelial cells, can affect the absorption and secretion of ions into the bloodstream. Collectively, they influence the homeostasis of these electrolytes in the host that, in turn, affects the risk of specific forms of nephrolithiasis. By their collateral effects on the microbiome, antibiotic treatments will select for microbial taxa that can affect multiple physiologic processes. The microbiota perturbations may be brief or prolonged, and they can lead to either short- or long-term physiologic changes that can promote metabolic diseases.
See this image and copyright information in PMC

Comment on

  • Oral Antibiotic Exposure and Kidney Stone Disease.
    Tasian GE, Jemielita T, Goldfarb DS, Copelovitch L, Gerber JS, Wu Q, Denburg MR. Tasian GE, et al. J Am Soc Nephrol. 2018 Jun;29(6):1731-1740. doi: 10.1681/ASN.2017111213. Epub 2018 May 10. J Am Soc Nephrol. 2018. PMID: 29748329 Free PMC article.

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