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Review
. 2018 May 11;122(10):1344-1346.
doi: 10.1161/CIRCRESAHA.118.312753.

Clinical Experience With Regenerative Therapy in Heart Failure: Advancing Care With Cardiopoietic Stem Cell Interventions

Jozef Bartunek  1 , Andre Terzic  2 , Atta Behfar  2 , William Wijns  3
Affiliations
Review

Clinical Experience With Regenerative Therapy in Heart Failure: Advancing Care With Cardiopoietic Stem Cell Interventions

Jozef Bartunek et al. Circ Res. .

Abstract

Adoption of regenerative strategies for heart failure is challenged by mixed outcomes in clinical trials. Ongoing development plans strive to improve biotherapeutic potency, optimize delivery, standardize dosing, and target responsive patient populations. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART) program offers advanced experience in clinical development of next generation regenerative therapies.

Keywords: heart; heart failure; myocardial infarction; phenotype; standard of care.

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Figures

Figure
Figure
The CHART program has provided relevant learnings pertinent to an optimized biotherapeutics, an enhanced delivery system, and scoping of responsive individuals in the setting of the largest cardiopoietic stem cell therapy clinical trial to date.
See this image and copyright information in PMC

References

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